Ontology highlight
ABSTRACT:
SUBMITTER: Hudson ME
PROVIDER: S-EPMC2077284 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Hudson Michael E ME Pozdnyakova Irina I Haines Kenneth K Mor Gil G Snyder Michael M
Proceedings of the National Academy of Sciences of the United States of America 20071022 44
Ovarian cancer is a leading cause of deaths, yet many aspects of the biology of the disease and a routine means of its detection are lacking. We have used protein microarrays and autoantibodies from cancer patients to identify proteins that are aberrantly expressed in ovarian tissue. Sera from 30 cancer patients and 30 healthy individuals were used to probe microarrays containing 5,005 human proteins. Ninety-four antigens were identified that exhibited enhanced reactivity from sera in cancer pat ...[more]