Ontology highlight
ABSTRACT:
SUBMITTER: Willingham SB
PROVIDER: S-EPMC2083260 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Willingham Stephen B SB Bergstralh Daniel T DT O'Connor William W Morrison Amy C AC Taxman Debra J DJ Duncan Joseph A JA Barnoy Shoshana S Venkatesan Malabi M MM Flavell Richard A RA Deshmukh Mohanish M Hoffman Hal M HM Ting Jenny P-Y JP
Cell host & microbe 20070901 3
Cryopyrin (CIAS1, NLRP3) and ASC are components of the inflammasome, a multiprotein complex required for caspase-1 activation and cytokine IL-1beta production. CIAS1 mutations underlie autoinflammation characterized by excessive IL-1beta secretion. Disease-associated cryopyrin also causes a program of necrosis-like cell death in macrophages, the mechanistic details of which are unknown. We find that patient monocytes carrying disease-associated CIAS1 mutations exhibit excessive necrosis-like dea ...[more]