Phagocytosis by human neutrophils is stimulated by a unique fungal cell wall component.
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ABSTRACT:
SUBMITTER: Rubin-Bejerano I
PROVIDER: S-EPMC2083279 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Publications
Phagocytosis by human neutrophils is stimulated by a unique fungal cell wall component.
Rubin-Bejerano Ifat I Abeijon Claudia C Magnelli Paula P Grisafi Paula P Fink Gerald R GR
Cell host & microbe 20070701 1
Innate immunity depends upon recognition of surface features common to broad groups of pathogens. The glucose polymer beta-glucan has been implicated in fungal immune recognition. Fungal walls have two kinds of beta-glucan: beta-1,3-glucan and beta-1,6-glucan. Predominance of beta-1,3-glucan has led to the presumption that it is the key immunological determinant for neutrophils. Examining various beta-glucans for their ability to stimulate human neutrophils, we find that the minor cell wall comp ...[more]
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