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The Design and Synthesis of Highly Branched and Spherically Symmetric Fluorinated Oils and Amphiles.

ABSTRACT: A new emulsifier design principle, based on concepts borrowed from protein science, is proposed. Using this principle, a class of highly branched and spherically symmetric fluorinated oils and amphiles has been designed and synthesized, for potential applications in the construction of fluorocarbon nanoparticles. The Mitsunobu reaction was employed as the key step for introducing three perfluoro-tert-butoxyl groups into pentaerythritol derivatives with excellent yields and extremely simple isolation procedures. Due to the symmetric arrangement of the fluorine atoms, each fluorinated oil or amphile molecule gives one sharp singlet (19)F NMR signal.

SUBMITTER: Jiang ZX

PROVIDER: S-EPMC2083655 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature

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The Design and Synthesis of Highly Branched and Spherically Symmetric Fluorinated Oils and Amphiles.

Jiang Zhong-Xing ZX Yu Y Bruce YB

Tetrahedron 20070501 19

A new emulsifier design principle, based on concepts borrowed from protein science, is proposed. Using this principle, a class of highly branched and spherically symmetric fluorinated oils and amphiles has been designed and synthesized, for potential applications in the construction of fluorocarbon nanoparticles. The Mitsunobu reaction was employed as the key step for introducing three perfluoro-tert-butoxyl groups into pentaerythritol derivatives with excellent yields and extremely simple isola ...[more]

PMID: 18461118

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