Ontology highlight
ABSTRACT:
SUBMITTER: Jiang ZX
PROVIDER: S-EPMC2888522 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Jiang Zhong-Xing ZX Yu Y Bruce YB
Synthesis 20080101 2
Two novel, highly fluorinated macrocyclic chelators with highly branched and spherically symmetric fluorocarbon moieties have been designed and efficiently synthesized. This is achieved by conjugating a spherically symmetric fluorocarbon moiety to the macrocyclic chelator DOTA, with or without a flexible oligo-oxyethylene linker between these two parts. As a result of the spherical symmetry, all 27 fluorine atoms in each fluorinated chelator give a sharp singlet (19)F NMR signal. The hydrophilic ...[more]