Ontology highlight
ABSTRACT:
SUBMITTER: O'Neill BT
PROVIDER: S-EPMC2084219 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
O'Neill Brian T BT Kim Jaetaek J Wende Adam R AR Theobald Heather A HA Tuinei Joseph J Buchanan Jonathan J Guo Aili A Zaha Vlad G VG Davis Don K DK Schell John C JC Boudina Sihem S Wayment Benjamin B Litwin Sheldon E SE Shioi Tetsuo T Izumo Seigo S Birnbaum Morris J MJ Abel E Dale ED
Cell metabolism 20071001 4
Physiological cardiac hypertrophy is associated with mitochondrial adaptations that are characterized by activation of PGC-1alpha and increased fatty acid oxidative (FAO) capacity. It is widely accepted that phosphatidylinositol 3-kinase (PI3K) signaling to Akt1 is required for physiological cardiac growth. However, the signaling pathways that coordinate physiological hypertrophy and metabolic remodeling are incompletely understood. We show here that activation of PI3K is sufficient to increase ...[more]