Ontology highlight
ABSTRACT:
SUBMITTER: Rinn JL
PROVIDER: S-EPMC2084369 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Rinn John L JL Kertesz Michael M Wang Jordon K JK Squazzo Sharon L SL Xu Xiao X Brugmann Samantha A SA Goodnough L Henry LH Helms Jill A JA Farnham Peggy J PJ Segal Eran E Chang Howard Y HY
Cell 20070601 7
Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood. Here we characterize the transcriptional landscape of the four human HOX loci at five base pair resolution in 11 anatomic sites and identify 231 HOX ncRNAs that extend known transcribed regions by more than 30 kilobases. HOX ncRNAs are spatially expressed along developmental axes and possess unique sequence motifs, and their expression demarcates broad chromosomal domains of differential histone methylation an ...[more]