Ontology highlight
ABSTRACT:
SUBMITTER: Werner MS
PROVIDER: S-EPMC5697714 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Werner Michael S MS Ruthenburg Alexander J AJ
Cell reports 20150806 7
A number of long noncoding RNAs (lncRNAs) have been reported to regulate transcription via recruitment of chromatin modifiers or bridging distal enhancer elements to gene promoters. However, the generality of these modes of regulation and the mechanisms of chromatin attachment for thousands of unstudied human lncRNAs remain unclear. To address these questions, we performed stringent nuclear fractionation coupled to RNA sequencing. We provide genome-wide identification of human chromatin-associat ...[more]