Ontology highlight
ABSTRACT:
SUBMITTER: Hillebrands JL
PROVIDER: S-EPMC209313 | biostudies-literature | 2001 Jun
REPOSITORIES: biostudies-literature
Hillebrands J L JL Klatter F A FA van den Hurk B M BM Popa E R ER Nieuwenhuis P P Rozing J J
The Journal of clinical investigation 20010601 11
The development of transplant arteriosclerosis (TA) is today's most important problem in clinical organ transplantation. Histologically, TA is characterized by perivascular inflammation and progressive intimal thickening. Current thought on this process of vascular remodeling assumes that neointimal vascular smooth muscle (VSM) cells and endothelium in TA are graft-derived, holding that medial VSM cells proliferate and migrate into the subendothelial space in response to signals from inflammator ...[more]