The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3.
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ABSTRACT:
SUBMITTER: Soto H
PROVIDER: S-EPMC20954 | biostudies-literature | 1998 Jul
REPOSITORIES: biostudies-literature
Publications
The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3.
Soto H H Wang W W Strieter R M RM Copeland N G NG Gilbert D J DJ Jenkins N A NA Hedrick J J Zlotnik A A
Proceedings of the National Academy of Sciences of the United States of America 19980701 14
We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine, which binds to a CXC chemokine receptor. Like other ligands of this receptor, 6Ckine has angiostatic properties. 6Ckine is known to chemoattract ...[more]
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