Ontology highlight
ABSTRACT:
SUBMITTER: Rangel-Moreno J
PROVIDER: S-EPMC1965555 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Rangel-Moreno Javier J Moyron-Quiroz Juan E JE Hartson Louise L Kusser Kim K Randall Troy D TD
Proceedings of the National Academy of Sciences of the United States of America 20070611 25
CXC chemokine ligand 13 (CXCL13), CC chemokine ligand 21 (CCL21), and CCL19 are constitutively expressed in secondary lymphoid organs, where they control the placement of lymphocytes and dendritic cells. However, these chemokines are also inducibly expressed in the lung after influenza infection. Here we show that, in the absence of spleen and lymph nodes, the expression of homeostatic chemokines in the lung is essential for local B and T cell responses to influenza and for the development and o ...[more]