Ontology highlight
ABSTRACT:
SUBMITTER: Meijer HA
PROVIDER: S-EPMC2095794 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Meijer Hedda A HA Bushell Martin M Hill Kirsti K Gant Timothy W TW Willis Anne E AE Jones Peter P de Moor Cornelia H CH
Nucleic acids research 20071011 19
The length of the poly(A) tail of an mRNA plays an important role in translational efficiency, mRNA stability and mRNA degradation. Regulated polyadenylation and deadenylation of specific mRNAs is involved in oogenesis, embryonic development, spermatogenesis, cell cycle progression and synaptic plasticity. Here we report a new technique to analyse the length of poly(A) tails and to separate a mixed population of mRNAs into fractions dependent on the length of their poly(A) tails. The method can ...[more]