Ontology highlight
ABSTRACT:
SUBMITTER: Seshasayee D
PROVIDER: S-EPMC2096422 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Seshasayee Dhaya D Lee Wyne P WP Zhou Meijuan M Shu Jean J Suto Eric E Zhang Juan J Diehl Laurie L Austin Cary D CD Meng Y Gloria YG Tan Martha M Bullens Sherron L SL Seeber Stefan S Fuentes Maria E ME Labrijn Aran F AF Graus Yvo M F YM Miller Lisa A LA Schelegle Edward S ES Hyde Dallas M DM Wu Lawren C LC Hymowitz Sarah G SG Martin Flavius F
The Journal of clinical investigation 20071201 12
Thymic stromal lymphopoietin (TSLP) potently induces deregulation of Th2 responses, a hallmark feature of allergic inflammatory diseases such as asthma, atopic dermatitis, and allergic rhinitis. However, direct downstream in vivo mediators in the TSLP-induced atopic immune cascade have not been identified. In our current study, we have shown that OX40 ligand (OX40L) is a critical in vivo mediator of TSLP-mediated Th2 responses. Treating mice with OX40L-blocking antibodies substantially inhibited ...[more]