Unknown

Dataset Information

0

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.


ABSTRACT: Thymic stromal lymphopoietin (TSLP) potently induces deregulation of Th2 responses, a hallmark feature of allergic inflammatory diseases such as asthma, atopic dermatitis, and allergic rhinitis. However, direct downstream in vivo mediators in the TSLP-induced atopic immune cascade have not been identified. In our current study, we have shown that OX40 ligand (OX40L) is a critical in vivo mediator of TSLP-mediated Th2 responses. Treating mice with OX40L-blocking antibodies substantially inhibited immune responses induced by TSLP in the lung and skin, including Th2 inflammatory cell infiltration, cytokine secretion, and IgE production. OX40L-blocking antibodies also inhibited antigen-driven Th2 inflammation in mouse and nonhuman primate models of asthma. This treatment resulted in both blockade of the OX40-OX40L receptor-ligand interaction and depletion of OX40L-positive cells. The use of a blocking, OX40L-specific mAb thus presents a promising strategy for the treatment of allergic diseases associated with pathologic Th2 immune responses.

SUBMITTER: Seshasayee D 

PROVIDER: S-EPMC2096422 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications


Thymic stromal lymphopoietin (TSLP) potently induces deregulation of Th2 responses, a hallmark feature of allergic inflammatory diseases such as asthma, atopic dermatitis, and allergic rhinitis. However, direct downstream in vivo mediators in the TSLP-induced atopic immune cascade have not been identified. In our current study, we have shown that OX40 ligand (OX40L) is a critical in vivo mediator of TSLP-mediated Th2 responses. Treating mice with OX40L-blocking antibodies substantially inhibited  ...[more]

Similar Datasets

| S-EPMC3593657 | biostudies-literature
| S-EPMC4684822 | biostudies-literature
| S-EPMC2895428 | biostudies-literature
| S-EPMC3959827 | biostudies-literature
| S-EPMC3328620 | biostudies-literature
| S-EPMC4979369 | biostudies-literature
| S-EPMC6878172 | biostudies-literature
| S-EPMC4348967 | biostudies-literature
| S-EPMC4414492 | biostudies-literature
2013-10-22 | E-GEOD-41329 | biostudies-arrayexpress