Ontology highlight
ABSTRACT:
SUBMITTER: Appleton BA
PROVIDER: S-EPMC2099469 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Appleton Brent A BA Wu Ping P Maloney Janice J Yin JianPing J Liang Wei-Ching WC Stawicki Scott S Mortara Kyle K Bowman Krista K KK Elliott J Michael JM Desmarais William W Bazan J Fernando JF Bagri Anil A Tessier-Lavigne Marc M Koch Alexander W AW Wu Yan Y Watts Ryan J RJ Wiesmann Christian C
The EMBO journal 20071108 23
Neuropilins (Nrps) are co-receptors for class 3 semaphorins and vascular endothelial growth factors and important for the development of the nervous system and the vasculature. The extracellular portion of Nrp is composed of two domains that are essential for semaphorin binding (a1a2), two domains necessary for VEGF binding (b1b2), and one domain critical for receptor dimerization (c). We report several crystal structures of Nrp1 and Nrp2 fragments alone and in complex with antibodies that selec ...[more]