Unknown

Dataset Information

0

Structural insights for engineering binding proteins based on non-antibody scaffolds.


ABSTRACT: Engineered binding proteins derived from non-antibody scaffolds constitute an increasingly prominent class of reagents in both research and therapeutic applications. The growing number of crystal structures of these 'alternative' scaffold-based binding proteins in complex with their targets illustrate the mechanisms of molecular recognition that are common among these systems and those unique to each. This information is useful for critically assessing and improving/expanding engineering strategies. Furthermore, the structural features of these synthetic proteins produced under tightly controlled, directed evolution deepen our understanding of the underlying principles governing molecular recognition.

SUBMITTER: Gilbreth RN 

PROVIDER: S-EPMC3423532 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Structural insights for engineering binding proteins based on non-antibody scaffolds.

Gilbreth Ryan N RN   Koide Shohei S  

Current opinion in structural biology 20120627 4


Engineered binding proteins derived from non-antibody scaffolds constitute an increasingly prominent class of reagents in both research and therapeutic applications. The growing number of crystal structures of these 'alternative' scaffold-based binding proteins in complex with their targets illustrate the mechanisms of molecular recognition that are common among these systems and those unique to each. This information is useful for critically assessing and improving/expanding engineering strateg  ...[more]

Similar Datasets

| S-EPMC6389260 | biostudies-literature
| S-EPMC7682334 | biostudies-literature
| S-EPMC2756573 | biostudies-literature
| S-EPMC7915573 | biostudies-literature
| S-EPMC7408565 | biostudies-literature
| S-EPMC8470104 | biostudies-literature
| S-EPMC2099469 | biostudies-literature
| S-EPMC11299021 | biostudies-literature
| S-EPMC5692558 | biostudies-literature
| S-EPMC8171004 | biostudies-literature