Ontology highlight
ABSTRACT:
SUBMITTER: Gilbreth RN
PROVIDER: S-EPMC3423532 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Gilbreth Ryan N RN Koide Shohei S
Current opinion in structural biology 20120627 4
Engineered binding proteins derived from non-antibody scaffolds constitute an increasingly prominent class of reagents in both research and therapeutic applications. The growing number of crystal structures of these 'alternative' scaffold-based binding proteins in complex with their targets illustrate the mechanisms of molecular recognition that are common among these systems and those unique to each. This information is useful for critically assessing and improving/expanding engineering strateg ...[more]