Ontology highlight
ABSTRACT:
SUBMITTER: Hartlieb B
PROVIDER: S-EPMC2111399 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Hartlieb Bettina B Muziol Tadeusz T Weissenhorn Winfried W Becker Stephan S
Proceedings of the National Academy of Sciences of the United States of America 20070103 2
Transcription of the highly pathogenic Ebola virus depends on VP30, a nucleocapsid-associated Ebola virus-specific transcription factor. The transcription activator VP30 was shown to play an essential role in Ebola virus replication, most likely by stabilizing nascent mRNA. Here we present the crystal structure of the C-terminal domain (CTD) of VP30 (VP30(CTD)) at 2.0-A resolution. VP30(CTD) folds independently into a dimeric helical assembly. The VP30(CTD) dimers assemble into hexamers that are ...[more]