Ontology highlight
ABSTRACT:
SUBMITTER: Serafini P
PROVIDER: S-EPMC2118163 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Serafini Paolo P Meckel Kristen K Kelso Michael M Noonan Kimberly K Califano Joseph J Koch Wayne W Dolcetti Luigi L Bronte Vincenzo V Borrello Ivan I
The Journal of experimental medicine 20061113 12
Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil) are agents currently in clinical use for nonmalignant conditions. We report the use of PDE5 inhibitors as modulators of the antitumor immune response. In several mouse tumor models, PDE5 inhibition reverses tumor-induced immunosuppressive mechanisms and enables a measurable antitumor immune response to be generated that substantially delays tumor progression. In particular, sildenafil, down-regulates arginase 1 and nit ...[more]