Ontology highlight
ABSTRACT:
SUBMITTER: Deng J
PROVIDER: S-EPMC5809273 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Deng Jiehui J Wang Eric S ES Jenkins Russell W RW Li Shuai S Dries Ruben R Yates Kathleen K Chhabra Sandeep S Huang Wei W Liu Hongye H Aref Amir R AR Ivanova Elena E Paweletz Cloud P CP Bowden Michaela M Zhou Chensheng W CW Herter-Sprie Grit S GS Sorrentino Jessica A JA Bisi John E JE Lizotte Patrick H PH Merlino Ashley A AA Quinn Max M MM Bufe Lauren E LE Yang Annan A Zhang Yanxi Y Zhang Hua H Gao Peng P Chen Ting T Chen Ting T Cavanaugh Megan E ME Rode Amanda J AJ Haines Eric E Roberts Patrick J PJ Strum Jay C JC Richards William G WG Lorch Jochen H JH Parangi Sareh S Gunda Viswanath V Boland Genevieve M GM Bueno Raphael R Palakurthi Sangeetha S Freeman Gordon J GJ Ritz Jerome J Haining W Nicholas WN Sharpless Norman E NE Arthanari Haribabu H Shapiro Geoffrey I GI Barbie David A DA Gray Nathanael S NS Wong Kwok-Kin KK
Cancer discovery 20171103 2
Immune checkpoint blockade, exemplified by antibodies targeting the PD-1 receptor, can induce durable tumor regressions in some patients. To enhance the efficacy of existing immunotherapies, we screened for small molecules capable of increasing the activity of T cells suppressed by PD-1. Here, we show that short-term exposure to small-molecule inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) significantly enhances T-cell activation, contributing to antitumor effects <i>in vivo</i>, due in ...[more]