Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC2118172 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20061211 13
Activated T cells die when antigen disappears from animals. This death is caused by proteins related to Bcl-2. Two hypotheses have been suggested to explain the actions of the different types of Bcl-2 proteins. One hypothesis suggests that, when T cells prepare to die, Bak and Bax, the proteins that actually kill activated T cells, are released from antiapoptotic proteins such as Bcl-2 and Bcl-xl. Another hypothesis suggests that Bak and Bax are normally free and are triggered to kill cells by r ...[more]