Ontology highlight
ABSTRACT:
SUBMITTER: Bleicken S
PROVIDER: S-EPMC4849160 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Bleicken S S Hofhaus G G Ugarte-Uribe B B Schröder R R García-Sáez A J AJ
Cell death & disease 20160225
The proteins of the Bcl-2 family have a crucial role in mitochondrial outer membrane permeabilization during apoptosis and in the regulation of mitochondrial dynamics. Current models consider that Bax forms toroidal pores at mitochondria that are responsible for the release of cytochrome c, whereas Bcl-xL inhibits pore formation. However, how Bcl-2 proteins regulate mitochondrial fission and fusion remains poorly understood. By using a systematic analysis at the single vesicle level, we found th ...[more]