Ontology highlight
ABSTRACT:
SUBMITTER: Querec T
PROVIDER: S-EPMC2118210 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Querec Troy T Bennouna Soumaya S Alkan Sefik S Laouar Yasmina Y Gorden Keith K Flavell Richard R Akira Shizuo S Ahmed Rafi R Pulendran Bali B
The Journal of experimental medicine 20060206 2
The live attenuated yellow fever vaccine 17D (YF-17D) is one of the most effective vaccines available, with a 65-yr history of use in >400 million people globally. Despite this efficacy, there is presently no information about the immunological mechanisms by which YF-17D acts. Here, we present data that suggest that YF-17D activates multiple Toll-like receptors (TLRs) on dendritic cells (DCs) to elicit a broad spectrum of innate and adaptive immune responses. Specifically, YF-17D activates multi ...[more]