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Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.

ABSTRACT: Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs.

SUBMITTER: Tadokoro CE

PROVIDER: S-EPMC2118249 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature

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Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.

Tadokoro Carlos E CE Shakhar Guy G Shen Shiqian S Ding Yi Y Lino Andreia C AC Maraver Antonio A Lafaille Juan J JJ Dustin Michael L ML

The Journal of experimental medicine 20060313 3

Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the estab ...[more]

PMID: 16533880

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