Ontology highlight
ABSTRACT:
SUBMITTER: Kwon HK
PROVIDER: S-EPMC2836639 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Kwon Ho-Keun HK Lee Choong-Gu CG So Jae-Seon JS Chae Chang-Suk CS Hwang Ji-Sun JS Sahoo Anupama A Nam Jong Hee JH Rhee Joon Haeng JH Hwang Ki-Chul KC Im Sin-Hyeog SH
Proceedings of the National Academy of Sciences of the United States of America 20100113 5
The beneficial effects of probiotics have been described in many diseases, but the mechanism by which they modulate the immune system is poorly understood. In this study, we identified a mixture of probiotics that up-regulates CD4(+)Foxp3(+) regulatory T cells (Tregs). Administration of the probiotics mixture induced both T-cell and B-cell hyporesponsiveness and down-regulated T helper (Th) 1, Th2, and Th17 cytokines without apoptosis induction. It also induced generation of CD4(+)Foxp3(+) Tregs ...[more]