Ontology highlight
ABSTRACT:
SUBMITTER: Kryczek I
PROVIDER: S-EPMC2118300 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Kryczek Ilona I Zou Linhua L Rodriguez Paulo P Zhu Gefeng G Wei Shuang S Mottram Peter P Brumlik Michael M Cheng Pui P Curiel Tyler T Myers Leann L Lackner Andrew A Alvarez Xavier X Ochoa Augusto A Chen Lieping L Zou Weiping W
The Journal of experimental medicine 20060410 4
Tumor-associated macrophages are a prominent component of ovarian cancer stroma and contribute to tumor progression. B7-H4 is a recently identified B7 family molecule. We show that primary ovarian tumor cells express intracellular B7-H4, whereas a fraction of tumor macrophages expresses surface B7-H4. B7-H4+ tumor macrophages, but not primary ovarian tumor cells, suppress tumor-associated antigen-specific T cell immunity. Blocking B7-H4-, but not arginase-, inducible nitric oxide synthase or B7- ...[more]