Ontology highlight
ABSTRACT:
SUBMITTER: MacGregor HL
PROVIDER: S-EPMC6844312 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
MacGregor Heather L HL Garcia-Batres Carlos C Sayad Azin A Elia Andrew A Berman Hal K HK Toker Aras A Katz Sarah Rachel SR Shaw Patricia A PA Clarke Blaise A BA Crome Sarah Q SQ Robert-Tissot Celine C Bernardini Marcus Q MQ Nguyen Linh T LT Ohashi Pamela S PS
Oncoimmunology 20190930 12
B7-H4, an immune suppressive member of the B7 family, is highly expressed in a wide variety of human malignancies making it an attractive immunotherapeutic target. However, the association between B7-H4 expression in the tumor microenvironment and the immune infiltrate has not been comprehensively examined. To evaluate the immune tumor microenvironment, we analyzed epithelial ovarian tumors from 28 patients using flow cytometry, immunohistochemistry, functional, and genomic analyses. We determin ...[more]