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Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.

ABSTRACT: Caspase-1 is activated by a variety of stimuli after the assembly of the "inflammasome," an activating platform made up of a complex of the NOD-LRR family of proteins. Caspase-1 is required for the secretion of proinflammatory cytokines, such as interleukin (IL)-1beta and IL-18, and is involved in the control of many bacterial infections. Paradoxically, however, its absence has been reported to confer resistance to oral infection by Salmonella typhimurium. We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection.

SUBMITTER: Lara-Tejero M

PROVIDER: S-EPMC2118315 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.

Lara-Tejero Maria M Sutterwala Fayyaz S FS Ogura Yasunori Y Grant Ethan P EP Bertin John J Coyle Anthony J AJ Flavell Richard A RA Galán Jorge E JE

The Journal of experimental medicine 20060522 6

Caspase-1 is activated by a variety of stimuli after the assembly of the "inflammasome," an activating platform made up of a complex of the NOD-LRR family of proteins. Caspase-1 is required for the secretion of proinflammatory cytokines, such as interleukin (IL)-1beta and IL-18, and is involved in the control of many bacterial infections. Paradoxically, however, its absence has been reported to confer resistance to oral infection by Salmonella typhimurium. We show here that absence of caspase-1 ...[more]

PMID: 16717117

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