Ontology highlight
ABSTRACT:
SUBMITTER: Lahl K
PROVIDER: S-EPMC2118432 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Lahl Katharina K Loddenkemper Christoph C Drouin Cathy C Freyer Jennifer J Arnason Jon J Eberl Gérard G Hamann Alf A Wagner Hermann H Huehn Jochen J Sparwasser Tim T
The Journal of experimental medicine 20070102 1
The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3-4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3 has been identified as the molecular cause of this multiorgan autoimmune disease. Foxp3 is a central control element in the development and function of regulatory T cells (T reg cells), which are necessary for the maintenance of self-tolerance. However, it is unclear whether dysfunction or a lack of T re ...[more]