Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover.
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ABSTRACT:
SUBMITTER: Almeida JR
PROVIDER: S-EPMC2118466 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
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Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover.
Almeida Jorge R JR Price David A DA Papagno Laura L Arkoub Zaïna Aït ZA Sauce Delphine D Bornstein Ethan E Asher Tedi E TE Samri Assia A Schnuriger Aurélie A Theodorou Ioannis I Costagliola Dominique D Rouzioux Christine C Agut Henri H Marcelin Anne-Geneviève AG Douek Daniel D Autran Brigitte B Appay Victor V
The Journal of experimental medicine 20070924 10
The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV) infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in particular, the immunodominant p24 epitope KK10 correlate with control of HIV-1 replication in human histocompatibility leukocyte antigen (HLA)-B27 patients. To understand further the nature of CD8+ T cell-mediated antiviral efficacy, we performed a comprehensive study of CD8+ T cells specific for the HLA-B27-restricte ...[more]
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