Ontology highlight
ABSTRACT:
SUBMITTER: Mkhwanazi N
PROVIDER: S-EPMC2954365 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Mkhwanazi Nompumelelo N Thobakgale Christina F CF van der Stok Mary M Reddy Shabashini S Mncube Zenele Z Chonco Fundisiwe F Walker Bruce D BD Altfeld Marcus M Goulder Philip J R PJ Ndung'u Thumbi T
Virology 20100717 2
HIV-1 specific HLA-B-restricted CD8+ T cell responses differ from HLA-C-restricted responses in antiviral effectiveness. To investigate possible reasons for these differences, we characterized the frequency and polyfunctionality of immmunodominant HLA-B*57/B5801- and HLA-Cw*07-restricted CD8+ T cells occurring concurrently in nine study subjects assessing IFN-gamma, TNF-alpha, IL-2, MIP-1beta, and CD107a by flow cytometry and analyzed sequence variation in targeted epitopes. HLA-B*57/5801 and HL ...[more]