Ontology highlight
ABSTRACT:
SUBMITTER: McCaughtry TM
PROVIDER: S-EPMC2118501 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
McCaughtry Tom M TM Wilken Matthew S MS Hogquist Kristin A KA
The Journal of experimental medicine 20071001 11
Conventional alphabeta T cell precursors undergo positive selection in the thymic cortex. When this is successful, they migrate to the medulla and are exposed to tissue-specific antigens (TSA) for purposes of central tolerance, and they undergo maturation to become functionally responsive T cells. It is commonly understood that thymocytes spend up to 2 wk in the medulla undergoing these final maturation steps before emigrating to peripheral lymphoid tissues. In addition, emigration is thought to ...[more]