Ontology highlight
ABSTRACT:
SUBMITTER: Hikono H
PROVIDER: S-EPMC2118640 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Hikono Hirokazu H Kohlmeier Jacob E JE Takamura Shiki S Wittmer Susan T ST Roberts Alan D AD Woodland David L DL
The Journal of experimental medicine 20070702 7
The contributions of different subsets of memory CD8+ T cells to recall responses at mucosal sites of infection are poorly understood. Here, we analyzed the CD8+ T cell recall responses to respiratory virus infection in mice and demonstrate that activation markers, such as CD27 and CD43, define three distinct subpopulations of memory CD8+ T cells that differ in their capacities to mount recall responses. These subpopulations are distinct from effector- and central-memory subsets, coordinately ex ...[more]