Ontology highlight
ABSTRACT:
SUBMITTER: Zloza A
PROVIDER: S-EPMC3436127 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Zloza Andrew A Kohlhapp Frederick J FJ Lyons Gretchen E GE Schenkel Jason M JM Moore Tamson V TV Lacek Andrew T AT O'Sullivan Jeremy A JA Varanasi Vineeth V Williams Jesse W JW Jagoda Michael C MC Bellavance Emily C EC Marzo Amanda L AL Thomas Paul G PG Zafirova Biljana B Polić Bojan B Al-Harthi Lena L Sperling Anne I AI Guevara-Patiño José A JA
Nature medicine 20120226 3
CD4-unhelped CD8(+) T cells are functionally defective T cells primed in the absence of CD4(+) T cell help. Given the co-stimulatory role of natural-killer group 2, member D protein (NKG2D) on CD8(+) T cells, we investigated its ability to rescue these immunologically impotent cells. We demonstrate that augmented co-stimulation through NKG2D during priming paradoxically rescues memory, but not effector, CD8(+) T cell responses. NKG2D-mediated rescue is characterized by reversal of elevated trans ...[more]