Ontology highlight
ABSTRACT:
SUBMITTER: Gorska MM
PROVIDER: S-EPMC2118652 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Gorska Magdalena M MM Liang Qiaoling Q Stafford Susan J SJ Goplen Nicolas N Dharajiya Nilesh N Guo Lei L Sur Sanjiv S Gaestel Matthias M Alam Rafeul R
The Journal of experimental medicine 20070625 7
We demonstrate that mitogen-activated protein kinase-activated kinase-2 (MK2) is essential for localized Th2-type inflammation and development of experimental asthma. MK2 deficiency does not affect systemic Th2 immunity, but reduces endothelial permeability, as well as adhesion molecule and chemokine expression. NF-kappaB regulates transcription of adhesion molecules and chemokines. We show that MK2 and its substrate HSP27 are essential for sustained NF-kappaB activation. MK2 and HSP27 prevent n ...[more]