Ontology highlight
ABSTRACT:
SUBMITTER: Kim E
PROVIDER: S-EPMC2121606 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Kim Eungseok E Ma Wen-Lung WL Lin Din-Lii DL Inui Shigeki S Chen Yuh-Ling YL Chang Chawnshang C
Biochemical and biophysical research communications 20070710 2
While Bcl-2 plays an important role in cell apoptosis, its relationship to the orphan nuclear receptors remains unclear. Here we report that mouse embryonic fibroblast (MEF) cells prepared from TR4-deficient (TR4(-/-)) mice are more susceptible to UV-irradiation mediated apoptosis compared to TR4-Wildtype (TR4(+/+)) littermates. Substantial increasing TR4(-/-) MEF apoptosis to UV-irradiation was correlated to the down-regulation of Bcl-2 RNA and protein expression and collaterally increased casp ...[more]