Ontology highlight
ABSTRACT:
SUBMITTER: Lin SJ
PROVIDER: S-EPMC4043245 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Lin Shin-Jen SJ Lee Soo Ok SO Lee Yi-Fen YF Miyamoto Hiroshi H Yang Dong-Rong DR Li Gonghui G Chang Chawnshang C
Carcinogenesis 20140228 6
Testicular nuclear receptor 4 (TR4), a member of the nuclear receptor superfamily, plays important roles in metabolism, fertility and aging. The linkage of TR4 functions in cancer progression, however, remains unclear. Using three different mouse models, we found TR4 could prevent or delay prostate cancer (PCa)/prostatic intraepithelial neoplasia development. Knocking down TR4 in human RWPE1 and mouse mPrE normal prostate cells promoted tumorigenesis under carcinogen challenge, suggesting TR4 ma ...[more]