Ontology highlight
ABSTRACT:
SUBMITTER: Mondal N
PROVIDER: S-EPMC212805 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Mondal Neelima N Zhang Ye Y Jonsson Zophonias Z Dhar Suman Kumar SK Kannapiran Madhu M Parvin Jeffrey D JD
Nucleic acids research 20030901 17
Transcription on chromatin by RNA polymerase II (pol II) is repressed as compared with transcription on histone-free DNA. In this study, we show that human topoisomerase I (topo I) and yeast topoisomerase II (topo II), each of which relax both positive and negative superhelical tension, reverse the transcriptional repression by chromatin. In the presence of bacterial topo I, which can relax only negative superhelical tension, the transcription is repressed on chromatin templates. The data togeth ...[more]