Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC5321744 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Lee Junwoo J Choi Eun Shik ES Seo Hogyu David HD Kang Keunsoo K Gilmore Joshua M JM Florens Laurence L Washburn Michael P MP Choe Joonho J Workman Jerry L JL Lee Daeyoup D
Nature communications 20170220
Previous studies have revealed that nucleosomes impede elongation of RNA polymerase II (RNAPII). Recent observations suggest a role for ATP-dependent chromatin remodellers in modulating this process, but direct in vivo evidence for this is unknown. Here using fission yeast, we identify Fun30<sup>Fft3</sup> as a chromatin remodeller, which localizes at transcribing regions to promote RNAPII transcription. Fun30<sup>Fft3</sup> associates with RNAPII and collaborates with the histone chaperone, FAC ...[more]