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The X family portrait: structural insights into biological functions of X family polymerases.

ABSTRACT: The mammalian family X DNA polymerases (DNA polymerases beta, lambda, mu, and TdT) contribute to base excision repair and double-strand break repair by virtue of their ability to fill short gaps in DNA. Structural information now exists for all four of these enzymes, making this the first mammalian polymerase family whose structural portrait is complete. Here we consider how distinctive structural features of these enzymes contribute to their biological functions in vivo.

SUBMITTER: Moon AF

PROVIDER: S-EPMC2128704 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature

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The X family portrait: structural insights into biological functions of X family polymerases.

Moon Andrea F AF Garcia-Diaz Miguel M Batra Vinod K VK Beard William A WA Bebenek Katarzyna K Kunkel Thomas A TA Wilson Samuel H SH Pedersen Lars C LC

DNA repair 20070712 12

The mammalian family X DNA polymerases (DNA polymerases beta, lambda, mu, and TdT) contribute to base excision repair and double-strand break repair by virtue of their ability to fill short gaps in DNA. Structural information now exists for all four of these enzymes, making this the first mammalian polymerase family whose structural portrait is complete. Here we consider how distinctive structural features of these enzymes contribute to their biological functions in vivo. ...[more]

PMID: 17631059

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