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Structural diversity of the Y-family DNA polymerases.

ABSTRACT: The Y-family translesion DNA polymerases enable cells to tolerate many forms of DNA damage, yet these enzymes have the potential to create genetic mutations at high rates. Although this polymerase family was defined less than a decade ago, more than 90 structures have already been determined so far. These structures show that the individual family members bypass damage and replicate DNA with either error-free or mutagenic outcomes, depending on the polymerase, the lesion and the sequence context. Here, these structures are reviewed and implications for polymerase function are discussed.

SUBMITTER: Pata JD

PROVIDER: S-EPMC2846201 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Structural diversity of the Y-family DNA polymerases.

Pata Janice D JD

Biochimica et biophysica acta 20100201 5

The Y-family translesion DNA polymerases enable cells to tolerate many forms of DNA damage, yet these enzymes have the potential to create genetic mutations at high rates. Although this polymerase family was defined less than a decade ago, more than 90 structures have already been determined so far. These structures show that the individual family members bypass damage and replicate DNA with either error-free or mutagenic outcomes, depending on the polymerase, the lesion and the sequence context ...[more]

PMID: 20123134

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