Ontology highlight
ABSTRACT:
SUBMITTER: Hermann GJ
PROVIDER: S-EPMC2132826 | biostudies-literature | 1998 Oct
REPOSITORIES: biostudies-literature
Hermann G J GJ Thatcher J W JW Mills J P JP Hales K G KG Fuller M T MT Nunnari J J Shaw J M JM
The Journal of cell biology 19981001 2
Membrane fusion is required to establish the morphology and cellular distribution of the mitochondrial compartment. In Drosophila, mutations in the fuzzy onions (fzo) GTPase block a developmentally regulated mitochondrial fusion event during spermatogenesis. Here we report that the yeast orthologue of fuzzy onions, Fzo1p, plays a direct and conserved role in mitochondrial fusion. A conditional fzo1 mutation causes the mitochondrial reticulum to fragment and blocks mitochondrial fusion during yea ...[more]