Ontology highlight
ABSTRACT:
SUBMITTER: Penkner A
PROVIDER: S-EPMC2140103 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Penkner Alexandra A Portik-Dobos Zsuzsanna Z Tang Lois L Schnabel Ralf R Novatchkova Maria M Jantsch Verena V Loidl Josef J
The EMBO journal 20071115 24
Genome stability relies on faithful DNA repair both in mitosis and in meiosis. Here, we report on a Caenorhabditis elegans protein that we found to be homologous to the mammalian repair-related protein CtIP and to the budding yeast Com1/Sae2 recombination protein. A com-1 mutant displays normal meiotic chromosome pairing but forms irregular chromatin aggregates instead of diakinesis bivalents. While meiotic DNA double-strand breaks (DSBs) are formed, they appear to persist or undergo improper re ...[more]