Ontology highlight
ABSTRACT:
SUBMITTER: Oishi I
PROVIDER: S-EPMC99585 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Oishi I I Iwai K K Kagohashi Y Y Fujimoto H H Kariya K K Kataoka T T Sawa H H Okano H H Otani H H Yamamura H H Minami Y Y
Molecular and cellular biology 20010201 4
Although chromosomal segregation at meiosis I is the critical process for genetic reassortment and inheritance, little is known about molecules involved in this process in metazoa. Here we show by utilizing double-stranded RNA (dsRNA)-mediated genetic interference that novel protein kinases (Ce-CDS-1 and Ce-CDS-2) related to Cds1 (Chk2) play an essential role in meiotic recombination in Caenorhabditis elegans. Injection of dsRNA into adult animals resulted in the inhibition of meiotic crossing o ...[more]