Ontology highlight
ABSTRACT:
SUBMITTER: Hom RA
PROVIDER: S-EPMC2144917 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Journal of molecular biology 20070821 2
Epsin and AP180 are essential components of the endocytotic machinery, which controls internalization of protein receptors and other macromolecules at the cell surface. Epsin and AP180 are recruited to the plasma membrane by their structurally and functionally related N-terminal ENTH and ANTH domains that specifically recognize PtdIns(4,5)P2. Here, we show that membrane anchoring of the ENTH and ANTH domains is regulated by the acidic environment. Lowering the pH enhances PtdIns(4,5)P2 affinity ...[more]