Ontology highlight
ABSTRACT:
SUBMITTER: Sakurai T
PROVIDER: S-EPMC7893821 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Sakurai Tetsuya T Kukimoto-Niino Mutsuko M Kunimura Kazufumi K Yamane Nana N Sakata Daiji D Aihara Ryosuke R Yasuda Tomoharu T Yokoyama Shigeyuki S Shirouzu Mikako M Fukui Yoshinori Y Uruno Takehito T
Life science alliance 20210211 4
DOCK8 is a Cdc42-specific guanine-nucleotide exchange factor that is essential for development and functions of various subsets of leukocytes in innate and acquired immune responses. Although DOCK8 plays a critical role in spatial control of Cdc42 activity during interstitial leukocyte migration, the mechanism remains unclear. We show that the DOCK homology region (DHR)-1 domain of DOCK8 binds specifically to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and is required for its recruitment t ...[more]