Ontology highlight
ABSTRACT:
SUBMITTER: Anders CK
PROVIDER: S-EPMC2148101 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Anders Carey K CK Acharya Chaitanya R CR Hsu David S DS Broadwater Gloria G Garman Katherine K Foekens John A JA Zhang Yi Y Wang Yixin Y Marcom Kelly K Marks Jeffrey R JR Mukherjee Sayan S Nevins Joseph R JR Blackwell Kimberly L KL Potti Anil A
PloS one 20080102 1
<h4>Purpose</h4>To define the biology driving the aggressive nature of breast cancer arising in young women.<h4>Experimental design</h4>Among 784 patients with early stage breast cancer, using prospectively-defined, age-specific cohorts (young <or=45 years; older >or=65 years), 411 eligible patients (n = 200<or=45 years; n = 211>or=65 years) with clinically-annotated Affymetrix microarray data were identified. GSEA, signatures of oncogenic pathway deregulation and predictors of chemotherapy sens ...[more]