Ontology highlight
ABSTRACT:
SUBMITTER: Henssen AG
PROVIDER: S-EPMC5489359 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nature genetics 20170515 7
Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly-based whole-genome DNA sequencing, we found previously undefined genomic rearrangements in human rhabdoid tumors. These rearrangements involved PGBD5-specific signal (PSS) sequences at their breakpoints and recurrently inactivate ...[more]