Ontology highlight
ABSTRACT:
SUBMITTER: Sadovsky E
PROVIDER: S-EPMC2148381 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Sadovsky Evgeniya E Yifrach Ofer O
Proceedings of the National Academy of Sciences of the United States of America 20071205 50
The information flow between distal elements of a protein may rely on allosteric communication trajectories lying along the protein's tertiary or quaternary structure. To unravel the underlying features of energy parsing along allosteric pathways in voltage-gated K(+) channels, high-order thermodynamic coupling analysis was performed. We report that such allosteric trajectories are functionally conserved and delineated by well defined boundaries. Moreover, allosteric trajectories assume a hierar ...[more]