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Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel.


ABSTRACT: The information flow between distal elements of a protein may rely on allosteric communication trajectories lying along the protein's tertiary or quaternary structure. To unravel the underlying features of energy parsing along allosteric pathways in voltage-gated K(+) channels, high-order thermodynamic coupling analysis was performed. We report that such allosteric trajectories are functionally conserved and delineated by well defined boundaries. Moreover, allosteric trajectories assume a hierarchical organization whereby increasingly stronger layers of cooperative residue interactions act to ensure efficient and cooperative long-range coupling between distal channel regions. Such long-range communication is brought about by a coupling of local and global conformational changes, suggesting that the allosteric trajectory also corresponds to a pathway of physical deformation. Supported by theoretical analyses and analogy to studies analyzing the contribution of long-range residue coupling to protein stability, we propose that such experimentally derived trajectory features are a general property of allosterically regulated proteins.

SUBMITTER: Sadovsky E 

PROVIDER: S-EPMC2148381 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature

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Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel.

Sadovsky Evgeniya E   Yifrach Ofer O  

Proceedings of the National Academy of Sciences of the United States of America 20071205 50


The information flow between distal elements of a protein may rely on allosteric communication trajectories lying along the protein's tertiary or quaternary structure. To unravel the underlying features of energy parsing along allosteric pathways in voltage-gated K(+) channels, high-order thermodynamic coupling analysis was performed. We report that such allosteric trajectories are functionally conserved and delineated by well defined boundaries. Moreover, allosteric trajectories assume a hierar  ...[more]

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