Ontology highlight
ABSTRACT:
SUBMITTER: Wylie BJ
PROVIDER: S-EPMC3890889 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Wylie Benjamin J BJ Bhate Manasi P MP McDermott Ann E AE
Proceedings of the National Academy of Sciences of the United States of America 20131216 1
It has been hypothesized that transmembrane allostery is the basis for inactivation of the potassium channel KcsA: opening the intracellular gate is spontaneously followed by ion expulsion at the extracellular selectivity filter. This suggests a corollary: following ion expulsion at neutral pH, a spontaneous global conformation change of the transmembrane helices, similar to the motion involved in opening, is expected. Consequently, both the low potassium state and the low pH state of the system ...[more]