Ontology highlight
ABSTRACT:
SUBMITTER: Sarmah B
PROVIDER: S-EPMC2148385 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Sarmah Bhaskarjyoti B Winfrey Virginia P VP Olson Gary E GE Appel Bruce B Wente Susan R SR
Proceedings of the National Academy of Sciences of the United States of America 20071203 50
Cilia project from cells as membranous extensions, with microtubule structural cores assembling from basal bodies by intraflagellar transport (IFT). Here, we report a ciliary role for the inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ipk1) that generates inositol hexakisphosphate. In zebrafish embryos, reducing Ipk1 levels inhibited ciliary beating in Kupffer's vesicle and decreased ciliary length in the spinal canal, pronephric ducts, and Kupffer's vesicle. Electron microscopy showed that cili ...[more]