Ontology highlight
ABSTRACT:
SUBMITTER: Rosa A
PROVIDER: S-EPMC2148386 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Rosa A A Ballarino M M Sorrentino A A Sthandier O O De Angelis F G FG Marchioni M M Masella B B Guarini A A Fatica A A Peschle C C Bozzoni I I
Proceedings of the National Academy of Sciences of the United States of America 20071203 50
We describe a pathway by which the master transcription factor PU.1 regulates human monocyte/macrophage differentiation. This includes miR-424 and the transcriptional factor NFI-A. We show that PU.1 and these two components are interlinked in a finely tuned temporal and regulatory circuitry: PU.1 activates the transcription of miR-424, and this up-regulation is involved in stimulating monocyte differentiation through miR-424-dependent translational repression of NFI-A. In turn, the decrease in N ...[more]